Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4971560..4972206 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NBY34_RS24035 Protein ID WP_016529833.1
Coordinates 4971859..4972206 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NBY34_RS24030 Protein ID WP_002920557.1
Coordinates 4971560..4971859 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS24010 (4967766) 4967766..4968524 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
NBY34_RS24015 (4968574) 4968574..4969404 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NBY34_RS24020 (4969455) 4969455..4969784 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NBY34_RS24025 (4969989) 4969989..4971497 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NBY34_RS24030 (4971560) 4971560..4971859 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NBY34_RS24035 (4971859) 4971859..4972206 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY34_RS24040 (4972372) 4972372..4974819 - 2448 WP_002920561.1 glycogen phosphorylase -
NBY34_RS24045 (4974837) 4974837..4976270 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T246770 WP_016529833.1 NZ_CP098165:c4972206-4971859 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT246770 WP_002920557.1 NZ_CP098165:c4971859-4971560 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References