Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2820354..2821043 Replicon chromosome
Accession NZ_CP098161
Organism Klebsiella pneumoniae strain Z0117KP0006

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag NBY36_RS13390 Protein ID WP_021469727.1
Coordinates 2820726..2821043 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag NBY36_RS13385 Protein ID WP_020804705.1
Coordinates 2820354..2820650 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY36_RS13370 (2816746) 2816746..2818128 + 1383 WP_004151222.1 MFS transporter -
NBY36_RS13375 (2818172) 2818172..2819788 + 1617 WP_004175961.1 carbohydrate porin -
NBY36_RS13380 (2819829) 2819829..2820275 - 447 WP_032435212.1 hypothetical protein -
NBY36_RS13385 (2820354) 2820354..2820650 - 297 WP_020804705.1 NadS family protein Antitoxin
NBY36_RS13390 (2820726) 2820726..2821043 - 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY36_RS13395 (2821250) 2821250..2821477 - 228 WP_002906690.1 tautomerase PptA -
NBY36_RS13400 (2821548) 2821548..2822165 - 618 WP_032425015.1 glutathione S-transferase family protein -
NBY36_RS13405 (2822243) 2822243..2823094 - 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
NBY36_RS13410 (2823133) 2823133..2823912 - 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
NBY36_RS13415 (2823896) 2823896..2824822 - 927 WP_032435210.1 amino acid ABC transporter permease -
NBY36_RS13420 (2824832) 2824832..2825341 - 510 WP_020802144.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T246748 WP_021469727.1 NZ_CP098161:c2821043-2820726 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT246748 WP_020804705.1 NZ_CP098161:c2820650-2820354 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References