Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2434474..2435163 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag NBY46_RS11905 Protein ID WP_021469727.1
Coordinates 2434474..2434791 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag NBY46_RS11910 Protein ID WP_020804705.1
Coordinates 2434867..2435163 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS11875 (2430176) 2430176..2430685 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
NBY46_RS11880 (2430695) 2430695..2431621 + 927 WP_032435210.1 amino acid ABC transporter permease -
NBY46_RS11885 (2431605) 2431605..2432384 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
NBY46_RS11890 (2432423) 2432423..2433274 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
NBY46_RS11895 (2433352) 2433352..2433969 + 618 WP_032425015.1 glutathione S-transferase family protein -
NBY46_RS11900 (2434040) 2434040..2434267 + 228 WP_002906690.1 tautomerase PptA -
NBY46_RS11905 (2434474) 2434474..2434791 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY46_RS11910 (2434867) 2434867..2435163 + 297 WP_020804705.1 NadS family protein Antitoxin
NBY46_RS11915 (2435242) 2435242..2435688 + 447 WP_032435212.1 hypothetical protein -
NBY46_RS11920 (2435729) 2435729..2437345 - 1617 WP_004175961.1 carbohydrate porin -
NBY46_RS11925 (2437389) 2437389..2438771 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T246717 WP_021469727.1 NZ_CP098149:2434474-2434791 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT246717 WP_020804705.1 NZ_CP098149:2434867-2435163 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References