Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4955636..4956282 Replicon chromosome
Accession NZ_CP098145
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NBY48_RS24155 Protein ID WP_016529833.1
Coordinates 4955935..4956282 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NBY48_RS24150 Protein ID WP_002920557.1
Coordinates 4955636..4955935 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS24130 (4951842) 4951842..4952600 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
NBY48_RS24135 (4952650) 4952650..4953480 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NBY48_RS24140 (4953531) 4953531..4953860 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NBY48_RS24145 (4954065) 4954065..4955573 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NBY48_RS24150 (4955636) 4955636..4955935 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NBY48_RS24155 (4955935) 4955935..4956282 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY48_RS24160 (4956448) 4956448..4958895 - 2448 WP_002920561.1 glycogen phosphorylase -
NBY48_RS24165 (4958913) 4958913..4960346 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T246705 WP_016529833.1 NZ_CP098145:c4956282-4955935 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT246705 WP_002920557.1 NZ_CP098145:c4955935-4955636 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References