Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2905412..2906101 Replicon chromosome
Accession NZ_CP098145
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag NBY48_RS14035 Protein ID WP_021469727.1
Coordinates 2905784..2906101 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag NBY48_RS14030 Protein ID WP_020804705.1
Coordinates 2905412..2905708 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS14015 (2901804) 2901804..2903186 + 1383 WP_004151222.1 MFS transporter -
NBY48_RS14020 (2903230) 2903230..2904846 + 1617 WP_004175961.1 carbohydrate porin -
NBY48_RS14025 (2904887) 2904887..2905333 - 447 WP_032435212.1 hypothetical protein -
NBY48_RS14030 (2905412) 2905412..2905708 - 297 WP_020804705.1 NadS family protein Antitoxin
NBY48_RS14035 (2905784) 2905784..2906101 - 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY48_RS14040 (2906308) 2906308..2906535 - 228 WP_002906690.1 tautomerase PptA -
NBY48_RS14045 (2906606) 2906606..2907223 - 618 WP_032425015.1 glutathione S-transferase family protein -
NBY48_RS14050 (2907301) 2907301..2908152 - 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
NBY48_RS14055 (2908191) 2908191..2908970 - 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
NBY48_RS14060 (2908954) 2908954..2909880 - 927 WP_032435210.1 amino acid ABC transporter permease -
NBY48_RS14065 (2909890) 2909890..2910399 - 510 WP_020802144.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T246699 WP_021469727.1 NZ_CP098145:c2906101-2905784 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT246699 WP_020804705.1 NZ_CP098145:c2905708-2905412 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References