Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4874802..4875448 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag NBY56_RS25315 Protein ID WP_032433636.1
Coordinates 4875101..4875448 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag NBY56_RS25310 Protein ID WP_019725405.1
Coordinates 4874802..4875101 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS25290 (4871008) 4871008..4871766 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
NBY56_RS25295 (4871816) 4871816..4872646 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NBY56_RS25300 (4872697) 4872697..4873026 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NBY56_RS25305 (4873231) 4873231..4874739 + 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
NBY56_RS25310 (4874802) 4874802..4875101 - 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
NBY56_RS25315 (4875101) 4875101..4875448 - 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY56_RS25320 (4875624) 4875624..4878071 - 2448 WP_032433638.1 glycogen phosphorylase -
NBY56_RS25325 (4878089) 4878089..4879522 - 1434 WP_032433640.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T246635 WP_032433636.1 NZ_CP098128:c4875448-4875101 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT246635 WP_019725405.1 NZ_CP098128:c4875101-4874802 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References