Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 32189..32781 Replicon plasmid p18001477_Rst
Accession NZ_CP098042
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name higB Uniprot ID Q7A225
Locus tag L3Q80_RS23605 Protein ID WP_011039853.1
Coordinates 32189..32467 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID L7Z874
Locus tag L3Q80_RS23610 Protein ID WP_011039854.1
Coordinates 32467..32781 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS23575 (L3Q80_23565) 27996..28904 + 909 WP_115163781.1 hypothetical protein -
L3Q80_RS23580 (L3Q80_23570) 28999..29205 + 207 WP_011039847.1 hypothetical protein -
L3Q80_RS23590 (L3Q80_23580) 29516..29968 + 453 WP_109910770.1 hypothetical protein -
L3Q80_RS23595 (L3Q80_23585) 31009..31251 + 243 WP_011039851.1 hypothetical protein -
L3Q80_RS23600 (L3Q80_23590) 31695..32033 + 339 WP_282557411.1 hypothetical protein -
L3Q80_RS23605 (L3Q80_23595) 32189..32467 + 279 WP_011039853.1 type II toxin-antitoxin system toxin endoribonuclease HigB Toxin
L3Q80_RS23610 (L3Q80_23600) 32467..32781 + 315 WP_011039854.1 type II toxin antitoxin system addiction module antidote protein HigA Antitoxin
L3Q80_RS23615 (L3Q80_23605) 33040..33549 + 510 WP_282557412.1 hypothetical protein -
L3Q80_RS24615 33608..34639 + 1032 WP_282557413.1 hypothetical protein -
L3Q80_RS23635 (L3Q80_23625) 34762..35199 + 438 WP_109910766.1 plasmid protein -
L3Q80_RS24620 35217..36734 + 1518 WP_282557414.1 hypothetical protein -
L3Q80_RS23650 (L3Q80_23640) 37042..37356 + 315 WP_109910763.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146248 146248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10742.22 Da        Isoelectric Point: 8.4392

>T246603 WP_011039853.1 NZ_CP098042:32189-32467 [Providencia rettgeri]
MIKSFKHKGLKLLFEKGVTSGVPAQDVDRINDRLQAIDTATEIGELNRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11536.99 Da        Isoelectric Point: 6.7241

>AT246603 WP_011039854.1 NZ_CP098042:32467-32781 [Providencia rettgeri]
MRQFKVSHPGEMIARDLEDMGVSGRRFAHNIGVTPATVSRLLAGKTALTPSLSIRIAAALGSTPEFWLRLQSNYDLRQLE
NQIDTSGIVLYGESNEQQQNAQEH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MCT
PDB 4YPB
PDB 4MCX
PDB 4YY3
PDB 4PX8
PDB 4ZSN
PDB 4W4G
PDB 5IWH
PDB 5IXL
PDB 4YZV

Antitoxin

Source ID Structure
PDB 4MCT
PDB 4MCX
PDB 6CHV
PDB 6CF1
AlphaFold DB A0A379FY56

References