Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4624945..4625675 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NAL25_RS22080 Protein ID WP_046897240.1
Coordinates 4624945..4625256 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NAL25_RS22085 Protein ID WP_182265462.1
Coordinates 4625253..4625675 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS22050 (NAL25_22025) 4620260..4620985 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
NAL25_RS22055 (NAL25_22030) 4621038..4622471 + 1434 WP_004937039.1 RNA polymerase factor sigma-54 -
NAL25_RS22060 (NAL25_22035) 4622495..4622782 + 288 WP_004937038.1 ribosome hibernation promoting factor -
NAL25_RS22065 (NAL25_22040) 4622938..4623399 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
NAL25_RS22070 (NAL25_22045) 4623527..4624381 + 855 WP_015379177.1 RNase adapter RapZ -
NAL25_RS22075 (NAL25_22050) 4624378..4624650 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
NAL25_RS22080 (NAL25_22055) 4624945..4625256 + 312 WP_046897240.1 type II toxin-antitoxin system HigB family toxin Toxin
NAL25_RS22085 (NAL25_22060) 4625253..4625675 + 423 WP_182265462.1 helix-turn-helix domain-containing protein Antitoxin
NAL25_RS22090 (NAL25_22065) 4625680..4627596 - 1917 WP_033644486.1 PRD domain-containing protein -
NAL25_RS22095 (NAL25_22070) 4627648..4628862 - 1215 WP_046897239.1 lactonase family protein -
NAL25_RS22100 (NAL25_22075) 4629074..4629814 - 741 WP_257711457.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12263.10 Da        Isoelectric Point: 10.1871

>T246586 WP_046897240.1 NZ_CP098030:4624945-4625256 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKHKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15775.12 Da        Isoelectric Point: 4.9650

>AT246586 WP_182265462.1 NZ_CP098030:4625253-4625675 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEQEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References