Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4568851..4569479 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NAL25_RS21775 Protein ID WP_046897263.1
Coordinates 4568851..4569141 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B4GQY7
Locus tag NAL25_RS21780 Protein ID WP_015379150.1
Coordinates 4569156..4569479 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS21765 (NAL25_21740) 4565426..4567447 + 2022 WP_046897265.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NAL25_RS21770 (NAL25_21745) 4567482..4568621 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NAL25_RS21775 (NAL25_21750) 4568851..4569141 + 291 WP_046897263.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NAL25_RS21780 (NAL25_21755) 4569156..4569479 + 324 WP_015379150.1 HigA family addiction module antitoxin Antitoxin
NAL25_RS21785 (NAL25_21760) 4569472..4569984 + 513 WP_042785417.1 M48 family metallopeptidase -
NAL25_RS21790 (NAL25_21765) 4570035..4571015 + 981 WP_075685009.1 Gfo/Idh/MocA family oxidoreductase -
NAL25_RS21795 (NAL25_21770) 4571017..4571748 + 732 WP_193550128.1 glutamine amidotransferase -
NAL25_RS21800 (NAL25_21775) 4572004..4572969 + 966 WP_193550146.1 TerC family protein -
NAL25_RS21805 (NAL25_21780) 4573232..4574467 + 1236 WP_193550129.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11733.43 Da        Isoelectric Point: 10.3320

>T246585 WP_046897263.1 NZ_CP098030:4568851-4569141 [Serratia ureilytica]
MIKSFRDRYLEQFYLEGRRSRLIPGMLERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAERIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12141.78 Da        Isoelectric Point: 6.2285

>AT246585 WP_015379150.1 NZ_CP098030:4569156-4569479 [Serratia ureilytica]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GQY7

References