Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3477733..3478393 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NAL25_RS16705 Protein ID WP_182264170.1
Coordinates 3478040..3478393 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NAL25_RS16700 Protein ID WP_046896398.1
Coordinates 3477733..3478035 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS16680 (NAL25_16660) 3473336..3474250 - 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -
NAL25_RS16685 (NAL25_16665) 3474375..3475493 - 1119 WP_094143511.1 branched-chain amino acid ABC transporter substrate-binding protein -
NAL25_RS16695 (NAL25_16675) 3476099..3477307 - 1209 WP_182264171.1 aldose 1-epimerase family protein -
NAL25_RS16700 (NAL25_16680) 3477733..3478035 - 303 WP_046896398.1 XRE family transcriptional regulator Antitoxin
NAL25_RS16705 (NAL25_16685) 3478040..3478393 - 354 WP_182264170.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NAL25_RS16710 (NAL25_16690) 3478829..3480124 + 1296 WP_033643756.1 MFS transporter -
NAL25_RS16715 (NAL25_16695) 3480151..3480957 + 807 WP_257711046.1 substrate-binding domain-containing protein -
NAL25_RS16720 (NAL25_16700) 3480932..3481831 - 900 WP_046896395.1 LysR family transcriptional regulator -
NAL25_RS16725 (NAL25_16705) 3481934..3482299 - 366 WP_046896394.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13611.64 Da        Isoelectric Point: 8.7037

>T246580 WP_182264170.1 NZ_CP098030:c3478393-3478040 [Serratia ureilytica]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T246580 NZ_CP098030:c3478393-3478040 [Serratia ureilytica]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGAAAAAGGGCCCGGCTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGCATTCAGTGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGCGTCGGCATG
GTGCTTTGCGCGGGCAATAAAGCGGGCGATGAAAAACGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAATTGGCTGAACACACTAAAAGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11107.99 Da        Isoelectric Point: 6.4749

>AT246580 WP_046896398.1 NZ_CP098030:c3478035-3477733 [Serratia ureilytica]
MGRTLEQLIAEEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT246580 NZ_CP098030:c3478035-3477733 [Serratia ureilytica]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGAGGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References