Detailed information of TA system TA024657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2584322..2585027
• Replicon: chromosome
• Accession: NC_013959
• Organism: Sideroxydans lithotrophicus ES-1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: D5CN76
• Locus tag: SLIT_RS12725
• Protein ID: WP_013030671.1
• Coordinates: 2584722..2585027 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: D5CN75
• Locus tag: SLIT_RS12720
• Protein ID: WP_013030670.1
• Coordinates: 2584322..2584720 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLIT_RS12705	2579424..2581655	+	2232	WP_013030667.1	methionine--tRNA ligase	-
SLIT_RS12710	2581680..2583071	+	1392	WP_013030668.1	Si-specific NAD(P)(+) transhydrogenase	-
SLIT_RS15385	2583191..2584198	-	1008	WP_013030669.1	hypothetical protein	-
SLIT_RS12720	2584322..2584720	-	399	WP_013030670.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
SLIT_RS12725	2584722..2585027	-	306	WP_013030671.1	type II toxin-antitoxin system MqsR family toxin	Toxin
SLIT_RS12730	2585240..2585629	-	390	WP_013030672.1	bacteriohemerythrin	-
SLIT_RS12735	2585677..2586306	-	630	WP_013030673.1	V-type ATP synthase subunit D	-
SLIT_RS12740	2586303..2587697	-	1395	WP_013030674.1	V-type ATP synthase subunit B	-
SLIT_RS12745	2587694..2589493	-	1800	WP_013030675.1	V-type ATP synthase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2578757..2599551	20794

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-100)

Antitoxin

• Zinc finger, MqsA-type (5-47)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11169.00 Da
• Isoelectric Point: 9.9453

>T24657 WP_013030671.1 NC_013959:c2585027-2584722 [Sideroxydans lithotrophicus ES-1]
MEKKKPHYPLSEVQRVVEDRGVNAFTATALIGAAALGLSVEQAVAVVLGLKQKDLYKSMTTNADHKIWQDVYHATLKSGL
VAYIKVTLRENGTVVIQFKEK

Nucleotide

• Length: 306 bp

>T24657 NC_013959:c2585027-2584722 [Sideroxydans lithotrophicus ES-1]
ATGGAGAAAAAGAAACCGCATTACCCACTATCTGAAGTTCAACGAGTCGTTGAAGATCGCGGAGTCAATGCTTTTACCGC
TACTGCATTAATTGGCGCCGCCGCATTGGGGCTTTCAGTTGAGCAGGCGGTGGCTGTGGTTTTGGGACTCAAACAGAAGG
ATTTGTATAAGAGCATGACCACAAATGCCGATCACAAAATCTGGCAAGACGTGTATCACGCAACGTTGAAATCTGGATTG
GTGGCTTATATCAAAGTCACCTTGCGTGAAAACGGAACCGTTGTGATCCAATTTAAGGAGAAATGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14800.11 Da
• Isoelectric Point: 8.8500

>AT24657 WP_013030670.1 NC_013959:c2584720-2584322 [Sideroxydans lithotrophicus ES-1]
MKHLCLNCEKGDMVRTKKDSEIEYRGHRAIVRALDGWHCPECGEVEFAGKEGVRYAEALEKLRLKIDAEESAELARIRKK
LKLSQRRAAAIAGGGVNAFSRYENGKARPVAAVVNLFRLLEKHPELLDEIAA

Nucleotide

• Length: 399 bp

>AT24657 NC_013959:c2584720-2584322 [Sideroxydans lithotrophicus ES-1]
ATGAAACACCTGTGCCTGAATTGCGAAAAAGGCGACATGGTCCGCACCAAAAAAGATTCAGAGATTGAATATCGTGGCCA
CCGCGCCATTGTTCGTGCGCTGGATGGTTGGCATTGCCCTGAGTGCGGAGAGGTCGAGTTTGCTGGTAAGGAAGGTGTGC
GTTATGCAGAAGCCTTGGAAAAGCTGCGGCTGAAAATTGACGCAGAAGAATCCGCAGAACTGGCGCGAATTCGGAAAAAA
CTTAAGCTTTCGCAACGCCGTGCAGCTGCTATTGCCGGTGGCGGTGTCAATGCCTTTTCTCGATACGAAAATGGCAAAGC
GAGACCCGTGGCTGCAGTGGTCAACTTGTTCCGTCTATTGGAAAAACATCCTGAGTTACTTGACGAGATTGCGGCTTAG

Structures

Toxin

• AlphaFold DB: D5CN76

Antitoxin

• AlphaFold DB: D5CN75