Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2223483..2224063 Replicon chromosome
Accession NC_013959
Organism Sideroxydans lithotrophicus ES-1

Toxin (Protein)


Gene name higB Uniprot ID D5CUN5
Locus tag SLIT_RS10965 Protein ID WP_013030320.1
Coordinates 2223785..2224063 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag SLIT_RS10960 Protein ID WP_013030319.1
Coordinates 2223483..2223785 (-) Length 101 a.a.

Genomic Context

SLIT_RS10945SLIT_RS10950SLIT_RS10955SLIT_RS10970SLIT_RS10975SLIT_RS15320SLIT_RS10960SLIT_RS10965SLIT_RS10980
Location: 2220314..2222128 (1815 bp)
Type: Others
Protein ID: WP_013030316.1
Location: 2222236..2222736 (501 bp)
Type: Others
Protein ID: WP_013030317.1
Location: 2222838..2223209 (372 bp)
Type: Others
Protein ID: WP_013030318.1
Location: 2224257..2225675 (1419 bp)
Type: Others
Protein ID: WP_013030321.1
Location: 2225838..2226167 (330 bp)
Type: Others
Protein ID: WP_013030322.1
Location: 2226987..2228363 (1377 bp)
Type: Others
Protein ID: WP_013030324.1
Location: 2223483..2223785 (303 bp)
Type: Antitoxin
Protein ID: WP_013030319.1
Location: 2223785..2224063 (279 bp)
Type: Toxin
Protein ID: WP_013030320.1
Location: 2226196..2226588 (393 bp)
Type: Others
Protein ID: WP_013030323.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SLIT_RS109452220314..2222128+1815WP_013030316.1NERD domain-containing protein-
SLIT_RS109502222236..2222736+501WP_013030317.1hypothetical protein-
SLIT_RS109552222838..2223209+372WP_013030318.1hypothetical protein-
SLIT_RS109602223483..2223785-303WP_013030319.1HigA family addiction module antidote proteinAntitoxin
SLIT_RS109652223785..2224063-279WP_013030320.1type II toxin-antitoxin system RelE/ParE family toxinToxin
SLIT_RS109702224257..2225675+1419WP_013030321.1PAS domain S-box protein-
SLIT_RS109752225838..2226167+330WP_013030322.1DUF2007 domain-containing protein-
SLIT_RS109802226196..2226588-393WP_013030323.1S24 family peptidase-
SLIT_RS153202226987..2228363+1377WP_013030324.1adenylate/guanylate cyclase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2218119..223370715588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-87)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10639.20 Da        Isoelectric Point: 7.3169

>T24656 WP_013030320.1 NC_013959:c2224063-2223785 [Sideroxydans lithotrophicus ES-1]
MIKSFKHKGLERLFIKGTASGVQADYATRITLMLDAIDVADQVNELDLPGFRLHRLKGVKRNLWSVRVSANWRITFEFEN
GDAYILDLEDYH

Download         Length: 279 bp

>T24656 NC_013959:c2224063-2223785 [Sideroxydans lithotrophicus ES-1]
ATGATCAAGAGTTTCAAACATAAAGGACTTGAACGCCTGTTTATCAAAGGCACTGCCAGCGGCGTACAAGCTGACTACGC
CACACGTATTACCCTGATGCTCGACGCAATTGATGTTGCGGATCAGGTGAACGAATTGGACTTGCCCGGCTTCCGGCTGC
ATCGCCTGAAGGGCGTCAAGCGCAACTTGTGGAGCGTGAGAGTGTCGGCTAATTGGCGCATCACATTCGAGTTTGAAAAC
GGCGATGCCTATATACTGGACTTGGAGGATTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11199.96 Da        Isoelectric Point: 10.7844

>AT24656 WP_013030319.1 NC_013959:c2223785-2223483 [Sideroxydans lithotrophicus ES-1]
MDTLRNKKRAPTHPGTLLREVVLPELGITQGEFADRLGVSRRTVSEILHGRRPVTPDMAIRLGKLLGNGAGLWLRMQQAV
DVWTLEQEGDYTNIRQLKAA

Download         Length: 303 bp

>AT24656 NC_013959:c2223785-2223483 [Sideroxydans lithotrophicus ES-1]
ATGGATACTTTACGAAACAAAAAACGCGCACCCACTCACCCCGGCACATTGCTGCGTGAAGTGGTATTGCCCGAACTGGG
AATCACGCAAGGCGAGTTTGCCGACCGGCTGGGCGTGTCGCGCCGCACCGTGTCCGAAATTCTGCACGGACGCCGTCCGG
TTACGCCGGACATGGCGATCCGCTTGGGCAAATTGCTGGGCAATGGCGCAGGGCTGTGGTTGCGTATGCAACAAGCTGTG
GATGTGTGGACACTGGAACAGGAAGGCGATTACACAAACATCCGGCAACTCAAGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD5CUN5

Antitoxin

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Source
ID
Structure
No matching records found

References