Detailed information of TA system TA246550

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2732337..2732822
• Replicon: chromosome
• Accession: NZ_CP098025
• Organism: Enterococcus faecalis strain QZ076

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NAG05_RS13570
• Protein ID: WP_021164441.1
• Coordinates: 2732337..2732438 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2732613..2732822 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAG05_RS13545 (2727865)	2727865..2728818	-	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-
NAG05_RS13550 (2728857)	2728857..2729612	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
NAG05_RS13555 (2729609)	2729609..2730574	-	966	WP_016622541.1	iron chelate uptake ABC transporter family permease subunit	-
NAG05_RS13560 (2730571)	2730571..2731518	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
NAG05_RS13565 (2731703)	2731703..2732155	+	453	WP_002359057.1	YueI family protein	-
- (2732181)	2732181..2732388	+	208	NuclAT_3	-	-
- (2732218)	2732218..2732392	+	175	NuclAT_6	-	-
NAG05_RS13570 (2732337)	2732337..2732438	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2732613)	2732613..2732822	+	210	NuclAT_4	-	Antitoxin
- (2732647)	2732647..2732826	+	180	NuclAT_5	-	-
NAG05_RS13575 (2732771)	2732771..2732872	-	102	WP_075551663.1	putative holin-like toxin	-
NAG05_RS13580 (2733060)	2733060..2735330	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
NAG05_RS13585 (2735501)	2735501..2736001	+	501	WP_010709949.1	cysteine hydrolase family protein	-
NAG05_RS13590 (2736702)	2736702..2737598	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T246550 WP_021164441.1 NZ_CP098025:c2732438-2732337 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT246550 NZ_CP098025:2732613-2732822 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin