Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1447389..1448113 Replicon chromosome
Accession NZ_CP097983
Organism Pantoea alhagi strain NX-11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQ939_RS06720 Protein ID WP_250652194.1
Coordinates 1447802..1448113 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ939_RS06715 Protein ID WP_250652193.1
Coordinates 1447389..1447805 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ939_RS06690 (LQ939_06675) 1443668..1444453 + 786 WP_250652189.1 SDR family oxidoreductase -
LQ939_RS06695 (LQ939_06680) 1444562..1445215 + 654 WP_250652190.1 ATP-binding cassette domain-containing protein -
LQ939_RS06700 (LQ939_06685) 1445212..1445973 + 762 WP_250652191.1 iron export ABC transporter permease subunit FetB -
LQ939_RS06705 (LQ939_06690) 1445970..1446545 - 576 WP_250652192.1 DedA family protein -
LQ939_RS06710 (LQ939_06695) 1446723..1447310 + 588 WP_085067515.1 Yip1 family protein -
LQ939_RS06715 (LQ939_06700) 1447389..1447805 - 417 WP_250652193.1 helix-turn-helix domain-containing protein Antitoxin
LQ939_RS06720 (LQ939_06705) 1447802..1448113 - 312 WP_250652194.1 type II toxin-antitoxin system HigB family toxin Toxin
LQ939_RS06725 (LQ939_06710) 1448362..1449297 + 936 WP_250652195.1 D-alanyl-D-alanine endopeptidase -
LQ939_RS06730 (LQ939_06715) 1449302..1449844 - 543 WP_250652196.1 GNAT family N-acetyltransferase -
LQ939_RS06735 (LQ939_06720) 1450033..1452474 + 2442 WP_250652197.1 DUF3772 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12445.41 Da        Isoelectric Point: 10.1232

>T246535 WP_250652194.1 NZ_CP097983:c1448113-1447802 [Pantoea alhagi]
MHIITREPFDKAAKLFPNHALALDDLYRHLKRVRFTSPEDLKKTFPSLDRMKYREKWWVIDIGGGNLRVMFFADFEQGKI
FIKHIATHAEYDKLTDFYRRNKE

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15777.11 Da        Isoelectric Point: 5.0126

>AT246535 WP_250652193.1 NZ_CP097983:c1447805-1447389 [Pantoea alhagi]
MIFSDAIEAADSLVRILPLLGGSTCRKDYEEAVRLVEYLVEHQPDSPLIEMLTAKIDAYENNAPEFAEFNARIDTEPHGV
SLLRILMDQYGLNQTDFVKEIGQRSLVSRILKGERKLTLEHMRNLAKRFNIPVSRFVD

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References