246528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 85129..85843 Replicon chromosome
Accession NZ_CP097897
Organism Acetobacterium wieringae strain CH1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CHL1_RS00450 Protein ID WP_250934316.1
Coordinates 85481..85843 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CHL1_RS00445 Protein ID WP_084633667.1
Coordinates 85129..85488 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHL1_RS00420 (CHL1_000084) 80204..80884 - 681 WP_250934313.1 response regulator transcription factor -
CHL1_RS00425 (CHL1_000085) 81051..81725 + 675 WP_250934314.1 polyphosphate polymerase domain-containing protein -
CHL1_RS00430 (CHL1_000086) 81954..82625 + 672 WP_148636901.1 DUF4956 domain-containing protein -
CHL1_RS00435 (CHL1_000087) 82639..84678 + 2040 WP_250934315.1 CotH kinase family protein -
CHL1_RS00445 (CHL1_000089) 85129..85488 - 360 WP_084633667.1 helix-turn-helix domain-containing protein Antitoxin
CHL1_RS00450 (CHL1_000090) 85481..85843 - 363 WP_250934316.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHL1_RS00455 (CHL1_000091) 86805..87611 + 807 WP_250934317.1 hypothetical protein -
CHL1_RS00460 (CHL1_000092) 87707..88333 + 627 WP_250934318.1 hypothetical protein -
CHL1_RS00465 (CHL1_000093) 88684..89109 - 426 WP_250934319.1 DUF3788 domain-containing protein -
CHL1_RS00470 (CHL1_000094) 89552..89968 + 417 WP_250934320.1 SOS response-associated peptidase family protein -
CHL1_RS00475 (CHL1_000095) 89971..90201 + 231 WP_250934321.1 SOS response-associated peptidase -
CHL1_RS00480 (CHL1_000096) 90272..90640 + 369 WP_250934322.1 DUF1801 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14353.57 Da        Isoelectric Point: 9.9400

>T246528 WP_250934316.1 NZ_CP097897:c85843-85481 [Acetobacterium wieringae]
MHKILFYKDPKGNEPVLDFIRELSKKNDKDSRVNLNKINDYIQMLSKYGTKIGEPYIKHLESEIWEIRPLRNRIFFVAWV
DGSYVLLHQFIKKSQKTPKREIEQAKRELAFLKESGENNE

Download         Length: 363 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13424.87 Da        Isoelectric Point: 10.7792

>AT246528 WP_084633667.1 NZ_CP097897:c85488-85129 [Acetobacterium wieringae]
MNNKAIGSSWTDVRKEIFTPEEILESDLRVALMGEIIKARHDKGISQKKLEELSGVRQPVIARMERGSTDPKLTTVLKIL
EPLGMTLTIVPIKEKRMRLKPPFELNLSKNGGKHPIKRG

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References