Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1340320..1341013 Replicon chromosome
Accession NZ_CP097884
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NAG72_RS06425 Protein ID WP_000415584.1
Coordinates 1340320..1340616 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NAG72_RS06430 Protein ID WP_000650107.1
Coordinates 1340618..1341013 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG72_RS06390 (1335408) 1335408..1335722 - 315 WP_000958598.1 putative quinol monooxygenase -
NAG72_RS06395 (1335753) 1335753..1336334 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NAG72_RS06400 (1336653) 1336653..1336985 + 333 WP_000917684.1 DUF2645 family protein -
NAG72_RS06405 (1337031) 1337031..1338380 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NAG72_RS06410 (1338377) 1338377..1339036 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
NAG72_RS06415 (1339188) 1339188..1339580 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NAG72_RS06420 (1339633) 1339633..1340115 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NAG72_RS06425 (1340320) 1340320..1340616 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NAG72_RS06430 (1340618) 1340618..1341013 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NAG72_RS06435 (1341146) 1341146..1342753 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NAG72_RS06440 (1342891) 1342891..1345149 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T246489 WP_000415584.1 NZ_CP097884:1340320-1340616 [Escherichia coli str. K-12 substr. MG1655]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT246489 WP_000650107.1 NZ_CP097884:1340618-1341013 [Escherichia coli str. K-12 substr. MG1655]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References