Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3977783..3978195 Replicon chromosome
Accession NZ_CP097882
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NAG70_RS19480 Protein ID WP_000132601.1
Coordinates 3977854..3978195 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3977783..3977859 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG70_RS19470 (3974646) 3974646..3976235 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
NAG70_RS19475 (3976232) 3976232..3977626 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (3977783) 3977783..3977859 - 77 NuclAT_14 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_14 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_14 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_14 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_15 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_15 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_15 - Antitoxin
- (3977783) 3977783..3977859 - 77 NuclAT_15 - Antitoxin
NAG70_RS19480 (3977854) 3977854..3978195 + 342 WP_000132601.1 endoribonuclease SymE Toxin
NAG70_RS19485 (3978357) 3978357..3979736 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NAG70_RS19490 (3979736) 3979736..3980782 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T246454 WP_000132601.1 NZ_CP097882:3977854-3978195 [Escherichia coli str. K-12 substr. MG1655]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT246454 NZ_CP097882:c3977859-3977783 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References