246441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1779061..1779563 Replicon chromosome
Accession NZ_CP097882
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NAG70_RS08440 Protein ID WP_000767829.1
Coordinates 1779309..1779563 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NAG70_RS08435 Protein ID WP_001259255.1
Coordinates 1779061..1779312 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG70_RS08410 (1774239) 1774239..1775306 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NAG70_RS08415 (1775306) 1775306..1776376 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NAG70_RS08420 (1776373) 1776373..1777677 - 1305 WP_000009594.1 histidinol dehydrogenase -
NAG70_RS08425 (1777683) 1777683..1778582 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NAG70_RS08430 (1778728) 1778728..1778778 - 51 WP_001364200.1 his operon leader peptide -
NAG70_RS08435 (1779061) 1779061..1779312 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NAG70_RS08440 (1779309) 1779309..1779563 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NAG70_RS08445 (1779646) 1779646..1780470 + 825 WP_000754737.1 SDR family oxidoreductase -
NAG70_RS08450 (1780516) 1780516..1781445 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NAG70_RS08455 (1781660) 1781660..1781722 + 63 WP_010723108.1 membrane protein YoeI -
NAG70_RS08460 (1781712) 1781712..1783070 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NAG70_RS08465 (1783249) 1783249..1784307 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
NAG70_RS08470 (1784321) 1784321..1784548 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T246441 WP_000767829.1 NZ_CP097882:1779309-1779563 [Escherichia coli str. K-12 substr. MG1655]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT246441 WP_001259255.1 NZ_CP097882:1779061-1779312 [Escherichia coli str. K-12 substr. MG1655]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References