Detailed information of TA system TA246428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 3906984..3907396
• Replicon: chromosome
• Accession: NZ_CP097881
• Organism: Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: NAG69_RS19010
• Protein ID: WP_000132601.1
• Coordinates: 3907055..3907396 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3906984..3907060 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAG69_RS19000 (3903847)	3903847..3905436	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
NAG69_RS19005 (3905433)	3905433..3906827	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
- (3906984)	3906984..3907060	-	77	NuclAT_13	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_13	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_13	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_13	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_14	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_14	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_14	-	Antitoxin
- (3906984)	3906984..3907060	-	77	NuclAT_14	-	Antitoxin
NAG69_RS19010 (3907055)	3907055..3907396	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
NAG69_RS19015 (3907558)	3907558..3908937	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
NAG69_RS19020 (3908937)	3908937..3909983	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T246428 WP_000132601.1 NZ_CP097881:3907055-3907396 [Escherichia coli str. K-12 substr. MG1655]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT246428 NZ_CP097881:c3907060-3906984 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin