Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3598742..3599283 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag NAG69_RS17570 Protein ID WP_000615983.1
Coordinates 3599005..3599283 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag NAG69_RS17565 Protein ID WP_000729703.1
Coordinates 3598742..3599002 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS17545 (3594417) 3594417..3595202 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
NAG69_RS17550 (3595174) 3595174..3596886 + 1713 Protein_3427 flagellar biosynthesis protein FlhA -
NAG69_RS17555 (3597110) 3597110..3597607 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
NAG69_RS17560 (3597783) 3597783..3598532 - 750 WP_000056849.1 C40 family peptidase -
NAG69_RS17565 (3598742) 3598742..3599002 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NAG69_RS17570 (3599005) 3599005..3599283 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NAG69_RS17575 (3599439) 3599439..3600179 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NAG69_RS17580 (3600150) 3600150..3600917 - 768 WP_000333380.1 class II glutamine amidotransferase -
NAG69_RS17585 (3601123) 3601123..3601701 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T246427 WP_000615983.1 NZ_CP097881:3599005-3599283 [Escherichia coli str. K-12 substr. MG1655]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT246427 WP_000729703.1 NZ_CP097881:3598742-3599002 [Escherichia coli str. K-12 substr. MG1655]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References