246415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1794014..1794516 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NAG69_RS08530 Protein ID WP_000767829.1
Coordinates 1794262..1794516 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NAG69_RS08525 Protein ID WP_001259255.1
Coordinates 1794014..1794265 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS08500 (1789192) 1789192..1790259 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NAG69_RS08505 (1790259) 1790259..1791329 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NAG69_RS08510 (1791326) 1791326..1792630 - 1305 WP_000009594.1 histidinol dehydrogenase -
NAG69_RS08515 (1792636) 1792636..1793535 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NAG69_RS08520 (1793681) 1793681..1793731 - 51 WP_001364200.1 his operon leader peptide -
NAG69_RS08525 (1794014) 1794014..1794265 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NAG69_RS08530 (1794262) 1794262..1794516 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NAG69_RS08535 (1794599) 1794599..1795423 + 825 WP_000754737.1 SDR family oxidoreductase -
NAG69_RS08540 (1795469) 1795469..1796398 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NAG69_RS08545 (1796613) 1796613..1796675 + 63 WP_010723108.1 membrane protein YoeI -
NAG69_RS08550 (1796665) 1796665..1798023 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NAG69_RS08555 (1798202) 1798202..1799260 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
NAG69_RS08560 (1799274) 1799274..1799501 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T246415 WP_000767829.1 NZ_CP097881:1794262-1794516 [Escherichia coli str. K-12 substr. MG1655]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT246415 WP_001259255.1 NZ_CP097881:1794014-1794265 [Escherichia coli str. K-12 substr. MG1655]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References