Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 715185..715878 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NAG69_RS03485 Protein ID WP_000415584.1
Coordinates 715185..715481 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NAG69_RS03490 Protein ID WP_000650107.1
Coordinates 715483..715878 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS03450 (710273) 710273..710587 - 315 WP_000958598.1 putative quinol monooxygenase -
NAG69_RS03455 (710618) 710618..711199 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NAG69_RS03460 (711518) 711518..711850 + 333 WP_000917684.1 DUF2645 family protein -
NAG69_RS03465 (711896) 711896..713245 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NAG69_RS03470 (713242) 713242..713901 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
NAG69_RS03475 (714053) 714053..714445 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NAG69_RS03480 (714498) 714498..714980 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NAG69_RS03485 (715185) 715185..715481 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NAG69_RS03490 (715483) 715483..715878 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NAG69_RS03495 (716011) 716011..717618 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NAG69_RS03500 (717756) 717756..720014 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T246410 WP_000415584.1 NZ_CP097881:715185-715481 [Escherichia coli str. K-12 substr. MG1655]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT246410 WP_000650107.1 NZ_CP097881:715483-715878 [Escherichia coli str. K-12 substr. MG1655]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References