Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3706243..3706836 Replicon chromosome
Accession NZ_CP097870
Organism Thauera sp. GDN1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CKCBHOJB_RS17075 Protein ID WP_281049863.1
Coordinates 3706243..3706524 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKCBHOJB_RS17080 Protein ID WP_281049865.1
Coordinates 3706537..3706836 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKCBHOJB_RS17055 (CKCBHOJB_03411) 3701818..3702696 + 879 WP_281049860.1 NAD-dependent epimerase/dehydratase family protein -
CKCBHOJB_RS17060 (CKCBHOJB_03412) 3702801..3703721 + 921 WP_281049861.1 glycosyltransferase family 4 protein -
CKCBHOJB_RS17065 (CKCBHOJB_03413) 3703732..3704307 + 576 WP_281049862.1 acetyltransferase -
CKCBHOJB_RS17070 (CKCBHOJB_03414) 3704438..3706198 + 1761 WP_281051716.1 nucleoside-diphosphate sugar epimerase/dehydratase -
CKCBHOJB_RS17075 3706243..3706524 + 282 WP_281049863.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKCBHOJB_RS17080 (CKCBHOJB_03415) 3706537..3706836 + 300 WP_281049865.1 HigA family addiction module antitoxin Antitoxin
CKCBHOJB_RS17085 (CKCBHOJB_03416) 3706989..3707222 + 234 WP_281049866.1 type II toxin-antitoxin system VapB family antitoxin -
CKCBHOJB_RS17090 (CKCBHOJB_03417) 3707222..3707623 + 402 WP_281049867.1 tRNA(fMet)-specific endonuclease VapC -
CKCBHOJB_RS17095 (CKCBHOJB_03418) 3707806..3708060 + 255 WP_281049868.1 DUF2442 domain-containing protein -
CKCBHOJB_RS17100 (CKCBHOJB_03419) 3708213..3708491 + 279 WP_281049869.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CKCBHOJB_RS17105 (CKCBHOJB_03420) 3708518..3708841 + 324 WP_281049870.1 type II toxin-antitoxin system RelE/ParE family toxin -
CKCBHOJB_RS17110 (CKCBHOJB_03421) 3708901..3709470 - 570 WP_281049871.1 Uma2 family endonuclease -
CKCBHOJB_RS17115 (CKCBHOJB_03422) 3709570..3711369 - 1800 WP_281049872.1 lipid A export permease/ATP-binding protein MsbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gmd / fcl 3483069..3707240 224171
- flank IS/Tn - - 3700394..3701716 1322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10550.09 Da        Isoelectric Point: 9.3518

>T246403 WP_281049863.1 NZ_CP097870:3706243-3706524 [Thauera sp. GDN1]
MSILSFRCPLSAALFARERVARFANIEASARRKLVLLDAAKDLKDLRIPPGNRLEALSGNRAGQHSIRINDQWRVCFRWT
ADGAEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10995.61 Da        Isoelectric Point: 5.1881

>AT246403 WP_281049865.1 NZ_CP097870:3706537-3706836 [Thauera sp. GDN1]
MSEKLAPMHPGEVLREEFMVPLGLSSNALARALGVTAARINEIVREERGITADTALRLARYFGTSEDLWLNLQRRYDVER
ARDALGASLEAIVPMREAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References