246393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3032539..3033137 Replicon chromosome
Accession NZ_CP097858
Organism Vibrio owensii strain GL-605

Toxin (Protein)


Gene name higB Uniprot ID A0A7Z7VLH5
Locus tag M8C01_RS13950 Protein ID WP_054103799.1
Coordinates 3032539..3032862 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7Z7VJV6
Locus tag M8C01_RS13955 Protein ID WP_054103798.1
Coordinates 3032859..3033137 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8C01_RS13915 3027705..3028211 + 507 WP_023584043.1 GNAT family N-acetyltransferase -
M8C01_RS13920 3028252..3028638 - 387 WP_023584042.1 TraA family conjugative transfer protein -
M8C01_RS13925 3028635..3029207 - 573 WP_001944091.1 type IV conjugative transfer system lipoprotein TraV -
M8C01_RS13930 3029282..3030571 - 1290 WP_086597841.1 TraB/VirB10 family protein -
M8C01_RS13935 3030574..3031470 - 897 WP_086597854.1 type-F conjugative transfer system secretin TraK -
M8C01_RS13940 3031454..3032080 - 627 WP_000667170.1 TraE/TraK family type IV conjugative transfer system protein -
M8C01_RS13945 3032077..3032358 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
M8C01_RS13950 3032539..3032862 + 324 WP_054103799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8C01_RS13955 3032859..3033137 + 279 WP_054103798.1 helix-turn-helix transcriptional regulator Antitoxin
M8C01_RS13960 3033163..3033798 - 636 WP_029627967.1 DUF4400 domain-containing protein -
M8C01_RS13965 3033785..3034345 - 561 WP_122067048.1 conjugative transfer protein -
M8C01_RS13970 3034355..3036175 - 1821 WP_122067047.1 conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul2 / aph(3'')-Ib / aph(6)-Id / tet(59) - 3002833..3073041 70208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12295.35 Da        Isoelectric Point: 9.7658

>T246393 WP_054103799.1 NZ_CP097858:3032539-3032862 [Vibrio owensii]
MSWKIDFYDGVEEQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGKHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10503.05 Da        Isoelectric Point: 9.9393

>AT246393 WP_054103798.1 NZ_CP097858:3032859-3033137 [Vibrio owensii]
MSLQKLKQRALANADVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7VLH5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7VJV6

References