Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1548730..1549242 Replicon chromosome
Accession NZ_CP097843
Organism Streptococcus oralis strain HP01

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag M9H69_RS07900 Protein ID WP_095726222.1
Coordinates 1548730..1548984 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag M9H69_RS07905 Protein ID WP_000388572.1
Coordinates 1548988..1549242 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9H69_RS07880 (M9H69_07880) 1544006..1544320 - 315 WP_002874282.1 DNA-directed RNA polymerase subunit omega -
M9H69_RS07885 (M9H69_07885) 1544345..1544971 - 627 WP_000775043.1 guanylate kinase -
M9H69_RS07890 (M9H69_07890) 1545095..1546708 - 1614 WP_000404958.1 ribonuclease Y -
M9H69_RS07895 (M9H69_07895) 1546843..1548528 - 1686 WP_125421500.1 P-loop NTPase fold protein -
M9H69_RS07900 (M9H69_07900) 1548730..1548984 - 255 WP_095726222.1 Txe/YoeB family addiction module toxin Toxin
M9H69_RS07905 (M9H69_07905) 1548988..1549242 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M9H69_RS07910 (M9H69_07910) 1549375..1550472 - 1098 WP_250315324.1 nucleotidyltransferase -
M9H69_RS07915 (M9H69_07915) 1550482..1551222 - 741 WP_109289829.1 class I SAM-dependent methyltransferase -
M9H69_RS07920 (M9H69_07920) 1551674..1552027 - 354 WP_250315325.1 ribosome silencing factor -
M9H69_RS07925 (M9H69_07925) 1552028..1552621 - 594 WP_084852643.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
M9H69_RS07930 (M9H69_07930) 1552621..1553250 - 630 WP_000963713.1 nicotinate-nucleotide adenylyltransferase -
M9H69_RS07935 (M9H69_07935) 1553302..1553613 - 312 WP_000060171.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10172.67 Da        Isoelectric Point: 7.9716

>T246382 WP_095726222.1 NZ_CP097843:c1548984-1548730 [Streptococcus oralis]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDNIAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT246382 WP_000388572.1 NZ_CP097843:c1549242-1548988 [Streptococcus oralis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References