246373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4393124..4393968 Replicon chromosome
Accession NZ_CP097840
Organism Shigella flexneri strain A

Toxin (Protein)


Gene name itaT Uniprot ID A0A4P7TPN5
Locus tag M9382_RS22105 Protein ID WP_005060796.1
Coordinates 4393570..4393968 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag M9382_RS22100 Protein ID WP_005053053.1
Coordinates 4393124..4393435 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9382_RS22075 (4388594) 4388594..4389091 + 498 Protein_4294 COX aromatic rich motif-containing protein -
M9382_RS22080 (4389113) 4389113..4391104 + 1992 Protein_4295 cytochrome o ubiquinol oxidase subunit I -
M9382_RS22085 (4391094) 4391094..4391708 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M9382_RS22090 (4391708) 4391708..4392037 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M9382_RS22095 (4392049) 4392049..4392939 + 891 WP_000971356.1 heme o synthase -
M9382_RS22100 (4393124) 4393124..4393435 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
M9382_RS22105 (4393570) 4393570..4393968 + 399 WP_005060796.1 GNAT family N-acetyltransferase Toxin
M9382_RS22115 (4394864) 4394864..4397017 + 2154 WP_005060811.1 SEL1-like repeat protein -
M9382_RS22120 (4397070) 4397070..4398800 + 1731 WP_000645011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4394016..4394519 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(52-112)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14335.69 Da        Isoelectric Point: 9.1674

>T246373 WP_005060796.1 NZ_CP097840:4393570-4393968 [Shigella flexneri]
VRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKK
IHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 399 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT246373 WP_005053053.1 NZ_CP097840:4393124-4393435 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPN5

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References