Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4356168..4356786 Replicon chromosome
Accession NZ_CP097840
Organism Shigella flexneri strain A

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9382_RS21910 Protein ID WP_001291435.1
Coordinates 4356568..4356786 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag M9382_RS21905 Protein ID WP_000344797.1
Coordinates 4356168..4356542 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9382_RS21895 (4351257) 4351257..4352450 + 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9382_RS21900 (4352473) 4352473..4355622 + 3150 WP_001132485.1 efflux RND transporter permease AcrB -
M9382_RS21905 (4356168) 4356168..4356542 + 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
M9382_RS21910 (4356568) 4356568..4356786 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9382_RS21915 (4356958) 4356958..4357509 + 552 WP_000102577.1 maltose O-acetyltransferase -
M9382_RS21920 (4357625) 4357625..4358095 + 471 WP_000136192.1 YlaC family protein -
M9382_RS21925 (4358259) 4358259..4359809 + 1551 WP_005106783.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9382_RS21930 (4359851) 4359851..4360204 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M9382_RS21940 (4360583) 4360583..4360894 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4360924..4362252 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246372 WP_001291435.1 NZ_CP097840:4356568-4356786 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT246372 WP_000344797.1 NZ_CP097840:4356168-4356542 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References