Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-couple_hipB
Location 663636..664324 Replicon chromosome
Accession NC_013947
Organism Stackebrandtia nassauensis DSM 44728

Toxin (Protein)


Gene name HigB2 Uniprot ID D3Q6U3
Locus tag SNAS_RS03110 Protein ID WP_013015913.1
Coordinates 663941..664324 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SNAS_RS03105 Protein ID WP_013015912.1
Coordinates 663636..663941 (-) Length 102 a.a.

Genomic Context

SNAS_RS03090SNAS_RS03095SNAS_RS03130SNAS_RS03135SNAS_RS03140SNAS_RS03085SNAS_RS03100SNAS_RS03105SNAS_RS03110SNAS_RS03115SNAS_RS03120SNAS_RS33685SNAS_RS03125
Location: 660721..661581 (861 bp)
Type: Others
Protein ID: WP_013015909.1
Location: 661578..662228 (651 bp)
Type: Others
Protein ID: WP_013015910.1
Location: 667548..667895 (348 bp)
Type: Others
Protein ID: WP_013015918.1
Location: 668193..668435 (243 bp)
Type: Others
Protein ID: WP_144300383.1
Location: 668492..669013 (522 bp)
Type: Others
Protein ID: WP_144300384.1
Location: 659369..660580 (1212 bp)
Type: Others
Protein ID: WP_013015908.1
Location: 662404..663387 (984 bp)
Type: Others
Protein ID: WP_013015911.1
Location: 663636..663941 (306 bp)
Type: Antitoxin
Protein ID: WP_013015912.1
Location: 663941..664324 (384 bp)
Type: Toxin
Protein ID: WP_013015913.1
Location: 664666..665133 (468 bp)
Type: Others
Protein ID: WP_144300382.1
Location: 665185..666159 (975 bp)
Type: Others
Protein ID: WP_013015915.1
Location: 666295..666513 (219 bp)
Type: Others
Protein ID: WP_013015916.1
Location: 666520..667416 (897 bp)
Type: Others
Protein ID: WP_169313845.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SNAS_RS03085659369..660580-1212WP_013015908.1two-component sensor histidine kinase-
SNAS_RS03090660721..661581+861WP_013015909.1CPBP family intramembrane metalloprotease-
SNAS_RS03095661578..662228+651WP_013015910.1response regulator transcription factor-
SNAS_RS03100662404..663387-984WP_013015911.1prolipoprotein diacylglyceryl transferase-
SNAS_RS03105663636..663941-306WP_013015912.1helix-turn-helix domain-containing proteinAntitoxin
SNAS_RS03110663941..664324-384WP_013015913.1type II toxin-antitoxin system RelE/ParE family toxinToxin
SNAS_RS03115664666..665133-468WP_144300382.1hypothetical protein-
SNAS_RS03120665185..666159-975WP_013015915.1hypothetical protein-
SNAS_RS33685666295..666513-219WP_013015916.1DUF397 domain-containing protein-
SNAS_RS03125666520..667416-897WP_169313845.1helix-turn-helix transcriptional regulator-
SNAS_RS03130667548..667895+348WP_013015918.1hypothetical protein-
SNAS_RS03135668193..668435+243WP_144300383.1hypothetical protein-
SNAS_RS03140668492..669013+522WP_144300384.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-115)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14688.58 Da        Isoelectric Point: 7.3175

>T24635 WP_013015913.1 NC_013947:c664324-663941 [Stackebrandtia nassauensis DSM 44728]
VAGNYQLRFFKDVIEWIQQLQKEDPDSFEHVIAALERLQEHGPALRRPTVGAIEGSAYRHMRELRARNGSRVSIRLLFAF
DPERRAIFLVAGNKAGQRQWTVWYDKAVKEADARYAAYLDALNAEEE

Download         Length: 384 bp

>T24635 NC_013947:c664324-663941 [Stackebrandtia nassauensis DSM 44728]
GTGGCCGGTAACTATCAACTCCGCTTTTTCAAGGACGTCATCGAGTGGATTCAGCAGTTGCAGAAGGAGGACCCTGACAG
CTTTGAGCACGTGATCGCGGCCTTGGAGCGACTCCAAGAGCACGGGCCGGCCCTGCGGAGGCCGACGGTGGGCGCAATCG
AGGGCAGCGCGTATCGACATATGCGAGAACTTCGCGCACGGAACGGCTCGCGTGTCAGTATTCGGCTGTTGTTCGCGTTT
GACCCTGAACGTCGCGCTATCTTTTTGGTCGCAGGCAACAAGGCTGGTCAGCGTCAATGGACAGTTTGGTATGACAAGGC
CGTCAAGGAAGCGGACGCCCGGTACGCCGCGTACCTTGACGCACTAAATGCGGAGGAGGAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10972.45 Da        Isoelectric Point: 5.1373

>AT24635 WP_013015912.1 NC_013947:c663941-663636 [Stackebrandtia nassauensis DSM 44728]
MELRDMSELTSGISTEQRARIDAIKQEMIDAERGHELASLRKAQGLTQSQVAEAMGVTQGRISQIESGKTRLDTETMAAY
LHAIGGELTITATVGRLSIQL

Download         Length: 306 bp

>AT24635 NC_013947:c663941-663636 [Stackebrandtia nassauensis DSM 44728]
ATGGAACTTCGGGACATGTCCGAACTGACTTCTGGAATTTCCACGGAGCAGCGTGCCCGCATTGACGCGATCAAGCAGGA
AATGATTGACGCTGAACGCGGGCACGAGCTTGCCAGCTTGCGGAAGGCGCAGGGGCTTACCCAATCACAGGTAGCCGAGG
CTATGGGCGTAACTCAGGGACGGATAAGCCAAATCGAAAGCGGCAAAACGCGGTTGGACACCGAGACGATGGCCGCATAT
CTTCACGCCATTGGCGGTGAGCTGACAATCACGGCAACTGTTGGACGTCTGTCCATCCAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD3Q6U3

Antitoxin

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Source
ID
Structure
No matching records found

References