Detailed information of TA system TA246344

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1907596..1907821
• Replicon: chromosome
• Accession: NZ_CP097837
• Organism: Shigella flexneri strain B

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: M9380_RS09585
• Protein ID: WP_000813254.1
• Coordinates: 1907666..1907821 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1907596..1907654 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M9380_RS09545	1903597..1903766	+	170	Protein_1850	hypothetical protein	-
M9380_RS09550	1903912..1904655	+	744	WP_000788999.1	ATP-binding protein	-
M9380_RS09555	1904670..1905092	+	423	WP_001118167.1	DUF977 family protein	-
M9380_RS09560	1905150..1905506	+	357	WP_005048249.1	hypothetical protein	-
M9380_RS09565	1905599..1905817	+	219	WP_000256998.1	DUF4014 family protein	-
M9380_RS09570	1905819..1906184	+	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
M9380_RS09575	1906181..1906846	+	666	WP_000208062.1	hypothetical protein	-
M9380_RS09580	1906846..1907211	+	366	WP_000610655.1	DUF551 domain-containing protein	-
-	1907596..1907654	-	59	-	-	Antitoxin
M9380_RS09585	1907666..1907821	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
M9380_RS09595	1909158..1909757	+	600	WP_000940329.1	DUF1367 family protein	-
M9380_RS09600	1909757..1910047	+	291	WP_000228038.1	DUF1364 domain-containing protein	-
M9380_RS09605	1910044..1910598	+	555	WP_000640143.1	DUF1133 family protein	-
M9380_RS09610	1910739..1910924	+	186	WP_005049799.1	hypothetical protein	-
M9380_RS09615	1910986..1912142	+	1157	WP_094081550.1	IS3-like element IS600 family transposase	-
M9380_RS09620	1912135..1912695	+	561	WP_072075205.1	ORF6N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	1897030..1944313	47283

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T246344 WP_000813254.1 NZ_CP097837:1907666-1907821 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT246344 NZ_CP097837:c1907654-1907596 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin