Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 937041..937659 Replicon chromosome
Accession NZ_CP097837
Organism Shigella flexneri strain B

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9380_RS04515 Protein ID WP_001291435.1
Coordinates 937041..937259 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag M9380_RS04520 Protein ID WP_000344797.1
Coordinates 937285..937659 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9380_RS04485 (932933) 932933..933244 - 312 WP_000409911.1 MGMT family protein -
M9380_RS04495 (933623) 933623..933976 + 354 WP_000878140.1 DUF1428 domain-containing protein -
M9380_RS04500 (934018) 934018..935568 - 1551 WP_005106783.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9380_RS04505 (935732) 935732..936202 - 471 WP_000136192.1 YlaC family protein -
M9380_RS04510 (936318) 936318..936869 - 552 WP_000102577.1 maltose O-acetyltransferase -
M9380_RS04515 (937041) 937041..937259 - 219 WP_001291435.1 HHA domain-containing protein Toxin
M9380_RS04520 (937285) 937285..937659 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
M9380_RS04525 (938205) 938205..941354 - 3150 WP_001132485.1 efflux RND transporter permease AcrB -
M9380_RS04530 (941377) 941377..942570 - 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 931575..932903 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246341 WP_001291435.1 NZ_CP097837:c937259-937041 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT246341 WP_000344797.1 NZ_CP097837:c937659-937285 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References