246340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 899859..900703 Replicon chromosome
Accession NZ_CP097837
Organism Shigella flexneri strain B

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag M9380_RS04320 Protein ID WP_014532172.1
Coordinates 899859..900320 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag M9380_RS04325 Protein ID WP_005053053.1
Coordinates 900392..900703 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9380_RS04305 (895027) 895027..896757 - 1731 WP_000645011.1 hypothetical protein -
M9380_RS04310 (896810) 896810..898963 - 2154 WP_005060811.1 SEL1-like repeat protein -
M9380_RS04315 (899114) 899114..899811 + 698 WP_232046043.1 IS1 family transposase -
M9380_RS04320 (899859) 899859..900320 - 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
M9380_RS04325 (900392) 900392..900703 - 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
M9380_RS04330 (900888) 900888..901778 - 891 WP_000971356.1 heme o synthase -
M9380_RS04335 (901790) 901790..902119 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M9380_RS04340 (902119) 902119..902733 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M9380_RS04345 (902723) 902723..904714 - 1992 Protein_837 cytochrome o ubiquinol oxidase subunit I -
M9380_RS04350 (904736) 904736..905233 - 498 Protein_838 COX aromatic rich motif-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 899308..899811 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T246340 WP_014532172.1 NZ_CP097837:c900320-899859 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT246340 WP_005053053.1 NZ_CP097837:c900703-900392 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References