Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 818013..818707 Replicon chromosome
Accession NZ_CP097837
Organism Shigella flexneri strain B

Toxin (Protein)


Gene name yafO Uniprot ID Q0T7Q5
Locus tag M9380_RS03895 Protein ID WP_001263491.1
Coordinates 818013..818411 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID Q0T7Q4
Locus tag M9380_RS03900 Protein ID WP_000554759.1
Coordinates 818414..818707 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9380_RS03870 (813352) 813352..813810 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
M9380_RS03875 (814072) 814072..815529 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
M9380_RS03880 (815586) 815586..816200 - 615 Protein_744 peptide chain release factor H -
M9380_RS03885 (816262) 816262..817305 - 1044 WP_005060486.1 RNA ligase RtcB family protein -
M9380_RS03890 (817551) 817551..818003 - 453 WP_001059846.1 GNAT family N-acetyltransferase -
M9380_RS03895 (818013) 818013..818411 - 399 WP_001263491.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
M9380_RS03900 (818414) 818414..818707 - 294 WP_000554759.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
M9380_RS03905 (818759) 818759..819814 - 1056 WP_001226172.1 DNA polymerase IV -
M9380_RS03910 (819885) 819885..820670 - 786 WP_000207560.1 putative lateral flagellar export/assembly protein LafU -
M9380_RS03915 (820642) 820642..822354 + 1713 Protein_751 flagellar biosynthesis protein FlhA -
M9380_RS03920 (822571) 822571..823068 - 498 WP_000006251.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrA / gtrB / gmhA/lpcA 777839..854481 76642


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15457.86 Da        Isoelectric Point: 8.0949

>T246339 WP_001263491.1 NZ_CP097837:c818411-818013 [Shigella flexneri]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11232.82 Da        Isoelectric Point: 7.0153

>AT246339 WP_000554759.1 NZ_CP097837:c818707-818414 [Shigella flexneri]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
KQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPK7

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TR46

References