Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 2349909..2350753 Replicon chromosome
Accession NZ_CP097834
Organism Shigella flexneri strain C

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag M9379_RS12170 Protein ID WP_014532172.1
Coordinates 2350292..2350753 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag M9379_RS12165 Protein ID WP_005053053.1
Coordinates 2349909..2350220 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9379_RS12140 (2345379) 2345379..2345876 + 498 Protein_2365 COX aromatic rich motif-containing protein -
M9379_RS12145 (2345898) 2345898..2347889 + 1992 Protein_2366 cytochrome o ubiquinol oxidase subunit I -
M9379_RS12150 (2347879) 2347879..2348493 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M9379_RS12155 (2348493) 2348493..2348822 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M9379_RS12160 (2348834) 2348834..2349724 + 891 WP_000971356.1 heme o synthase -
M9379_RS12165 (2349909) 2349909..2350220 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
M9379_RS12170 (2350292) 2350292..2350753 + 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
M9379_RS12180 (2351649) 2351649..2353802 + 2154 WP_005060811.1 SEL1-like repeat protein -
M9379_RS12185 (2353855) 2353855..2355585 + 1731 WP_000645011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2350801..2351304 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T246328 WP_014532172.1 NZ_CP097834:2350292-2350753 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT246328 WP_005053053.1 NZ_CP097834:2349909-2350220 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References