Detailed information of TA system TA246319

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 685222..685447
• Replicon: chromosome
• Accession: NZ_CP097834
• Organism: Shigella flexneri strain C

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: M9379_RS03315
• Protein ID: WP_000813254.1
• Coordinates: 685292..685447 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	685222..685280 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M9379_RS03280	680409..681671	-	1263	Protein_642	tyrosine-type recombinase/integrase	-
M9379_RS03290	682009..682806	-	798	WP_024260703.1	DgsA anti-repressor MtfA	-
M9379_RS03300	683017..684057	-	1041	WP_005096324.1	tyrosine-type recombinase/integrase	-
M9379_RS03305	684057..684197	-	141	Protein_645	DUF4224 domain-containing protein	-
M9379_RS03310	684224..684640	+	417	WP_005069274.1	hypothetical protein	-
-	685222..685280	-	59	-	-	Antitoxin
M9379_RS03315	685292..685447	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
M9379_RS03320	685615..685893	+	279	WP_011069426.1	hypothetical protein	-
M9379_RS03325	685895..686953	+	1059	WP_001265248.1	DUF968 domain-containing protein	-
M9379_RS03330	686954..687319	+	366	WP_000140017.1	RusA family crossover junction endodeoxyribonuclease	-
M9379_RS03335	687316..688004	+	689	Protein_651	bacteriophage antitermination protein Q	-
M9379_RS03360	688800..689015	+	216	WP_000839572.1	class II holin family protein	-
M9379_RS03365	689114..689788	+	675	WP_004967157.1	IS66-like element accessory protein TnpA	-
M9379_RS03370	689785..690135	+	351	WP_005049241.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	645317..720014	74697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T246319 WP_000813254.1 NZ_CP097834:685292-685447 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT246319 NZ_CP097834:c685280-685222 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin