246312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4393940..4394784 Replicon chromosome
Accession NZ_CP097831
Organism Shigella flexneri strain D

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag M9381_RS22115 Protein ID WP_014532172.1
Coordinates 4394323..4394784 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag M9381_RS22110 Protein ID WP_005053053.1
Coordinates 4393940..4394251 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9381_RS22085 (4389410) 4389410..4389907 + 498 Protein_4296 COX aromatic rich motif-containing protein -
M9381_RS22090 (4389929) 4389929..4391920 + 1992 Protein_4297 cytochrome o ubiquinol oxidase subunit I -
M9381_RS22095 (4391910) 4391910..4392524 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M9381_RS22100 (4392524) 4392524..4392853 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M9381_RS22105 (4392865) 4392865..4393755 + 891 WP_000971356.1 heme o synthase -
M9381_RS22110 (4393940) 4393940..4394251 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
M9381_RS22115 (4394323) 4394323..4394784 + 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
M9381_RS22125 (4395680) 4395680..4397833 + 2154 WP_005060811.1 SEL1-like repeat protein -
M9381_RS22130 (4397886) 4397886..4399616 + 1731 WP_000645011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4394832..4395335 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T246312 WP_014532172.1 NZ_CP097831:4394323-4394784 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT246312 WP_005053053.1 NZ_CP097831:4393940-4394251 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References