Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4356984..4357602 Replicon chromosome
Accession NZ_CP097831
Organism Shigella flexneri strain D

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9381_RS21920 Protein ID WP_001291435.1
Coordinates 4357384..4357602 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag M9381_RS21915 Protein ID WP_000344797.1
Coordinates 4356984..4357358 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9381_RS21905 (4352073) 4352073..4353266 + 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9381_RS21910 (4353289) 4353289..4356438 + 3150 WP_001132485.1 efflux RND transporter permease AcrB -
M9381_RS21915 (4356984) 4356984..4357358 + 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
M9381_RS21920 (4357384) 4357384..4357602 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M9381_RS21925 (4357774) 4357774..4358325 + 552 WP_000102577.1 maltose O-acetyltransferase -
M9381_RS21930 (4358441) 4358441..4358911 + 471 WP_000136192.1 YlaC family protein -
M9381_RS21935 (4359075) 4359075..4360625 + 1551 WP_005106783.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9381_RS21940 (4360667) 4360667..4361020 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M9381_RS21950 (4361399) 4361399..4361710 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4361740..4363068 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246311 WP_001291435.1 NZ_CP097831:4357384-4357602 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT246311 WP_000344797.1 NZ_CP097831:4356984-4357358 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References