Detailed information of TA system TA246288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4003581..4003806
• Replicon: chromosome
• Accession: NZ_CP097828
• Organism: Shigella flexneri strain E

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: M9383_RS20080
• Protein ID: WP_000813254.1
• Coordinates: 4003651..4003806 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4003581..4003639 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M9383_RS20040	3999582..3999751	+	170	Protein_3891	hypothetical protein	-
M9383_RS20045	3999897..4000640	+	744	WP_000788999.1	ATP-binding protein	-
M9383_RS20050	4000655..4001077	+	423	WP_001118167.1	DUF977 family protein	-
M9383_RS20055	4001135..4001491	+	357	WP_005048249.1	hypothetical protein	-
M9383_RS20060	4001584..4001802	+	219	WP_000256998.1	DUF4014 family protein	-
M9383_RS20065	4001804..4002169	+	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
M9383_RS20070	4002166..4002831	+	666	WP_000208062.1	hypothetical protein	-
M9383_RS20075	4002831..4003196	+	366	WP_000610655.1	DUF551 domain-containing protein	-
-	4003581..4003639	-	59	-	-	Antitoxin
M9383_RS20080	4003651..4003806	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
M9383_RS20090	4005143..4005742	+	600	WP_000940329.1	DUF1367 family protein	-
M9383_RS20095	4005742..4006032	+	291	WP_000228038.1	DUF1364 domain-containing protein	-
M9383_RS20100	4006029..4006583	+	555	WP_000640143.1	DUF1133 family protein	-
M9383_RS20105	4006736..4006909	+	174	WP_000504450.1	hypothetical protein	-
M9383_RS20110	4006971..4008127	+	1157	WP_094081550.1	IS3-like element IS600 family transposase	-
M9383_RS20115	4008120..4008680	+	561	WP_072075205.1	ORF6N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	3993015..4055688	62673

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T246288 WP_000813254.1 NZ_CP097828:4003651-4003806 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT246288 NZ_CP097828:c4003639-4003581 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin