Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3033027..3033645 Replicon chromosome
Accession NZ_CP097828
Organism Shigella flexneri strain E

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M9383_RS15005 Protein ID WP_001291435.1
Coordinates 3033027..3033245 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag M9383_RS15010 Protein ID WP_000344797.1
Coordinates 3033271..3033645 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9383_RS14975 (3028919) 3028919..3029230 - 312 WP_000409911.1 MGMT family protein -
M9383_RS14985 (3029609) 3029609..3029962 + 354 WP_000878140.1 DUF1428 domain-containing protein -
M9383_RS14990 (3030004) 3030004..3031554 - 1551 WP_005106783.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M9383_RS14995 (3031718) 3031718..3032188 - 471 WP_000136192.1 YlaC family protein -
M9383_RS15000 (3032304) 3032304..3032855 - 552 WP_000102577.1 maltose O-acetyltransferase -
M9383_RS15005 (3033027) 3033027..3033245 - 219 WP_001291435.1 HHA domain-containing protein Toxin
M9383_RS15010 (3033271) 3033271..3033645 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
M9383_RS15015 (3034191) 3034191..3037340 - 3150 WP_001132485.1 efflux RND transporter permease AcrB -
M9383_RS15020 (3037363) 3037363..3038556 - 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3027561..3028889 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246285 WP_001291435.1 NZ_CP097828:c3033245-3033027 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT246285 WP_000344797.1 NZ_CP097828:c3033645-3033271 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References