Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4006807..4007404 Replicon chromosome
Accession NZ_CP097808
Organism Klebsiella variicola strain 17YN56

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag M9O80_RS19555 Protein ID WP_012542526.1
Coordinates 4007087..4007404 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9O80_RS19550 Protein ID WP_012542525.1
Coordinates 4006807..4007094 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O80_RS19520 (M9O80_19520) 4002762..4003010 + 249 WP_008805539.1 DUF1158 domain-containing protein -
M9O80_RS19525 (M9O80_19525) 4003027..4003368 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
M9O80_RS19530 (M9O80_19530) 4003399..4004514 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
M9O80_RS19535 (M9O80_19535) 4004694..4005275 + 582 WP_046881940.1 TetR/AcrR family transcriptional regulator -
M9O80_RS19540 (M9O80_19540) 4005275..4005643 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
M9O80_RS19545 (M9O80_19545) 4005763..4006416 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
M9O80_RS19550 (M9O80_19550) 4006807..4007094 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
M9O80_RS19555 (M9O80_19555) 4007087..4007404 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O80_RS19560 (M9O80_19560) 4007589..4008632 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
M9O80_RS19565 (M9O80_19565) 4009161..4010027 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
M9O80_RS19570 (M9O80_19570) 4010136..4011563 + 1428 WP_117121081.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T246271 WP_012542526.1 NZ_CP097808:c4007404-4007087 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT246271 WP_012542525.1 NZ_CP097808:c4007094-4006807 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References