Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2299295..2300006 Replicon chromosome
Accession NZ_CP097799
Organism Pasteurella multocida strain 39639

Toxin (Protein)


Gene name higB Uniprot ID A0A8E2A4A3
Locus tag M9410_RS10920 Protein ID WP_032854112.1
Coordinates 2299680..2300006 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9410_RS10915 Protein ID WP_005757699.1
Coordinates 2299295..2299621 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9410_RS10895 (M9410_10895) 2294733..2295764 + 1032 WP_005757705.1 hypothetical protein -
M9410_RS10900 (M9410_10900) 2296002..2297009 + 1008 WP_005755103.1 hypothetical protein -
M9410_RS10905 (M9410_10905) 2297060..2297662 + 603 WP_005757703.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M9410_RS10910 (M9410_10910) 2297721..2299241 + 1521 WP_005757701.1 surface lipoprotein assembly modifier -
M9410_RS10915 (M9410_10915) 2299295..2299621 - 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M9410_RS10920 (M9410_10920) 2299680..2300006 - 327 WP_032854112.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9410_RS10925 (M9410_10925) 2300164..2300640 + 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M9410_RS10930 (M9410_10930) 2300714..2301584 - 871 Protein_2107 VirK/YbjX family protein -
M9410_RS10935 (M9410_10935) 2301695..2302312 + 618 WP_005755089.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M9410_RS10940 (M9410_10940) 2302420..2303949 + 1530 WP_005757692.1 YifB family Mg chelatase-like AAA ATPase -
M9410_RS10945 (M9410_10945) 2304003..2304689 - 687 WP_005757690.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12832.64 Da        Isoelectric Point: 9.6705

>T246251 WP_032854112.1 NZ_CP097799:c2300006-2299680 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNSPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT246251 WP_005757699.1 NZ_CP097799:c2299621-2299295 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References