246243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2287388..2288134 Replicon chromosome
Accession NZ_CP097795
Organism Pasteurella multocida strain 34030

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M9414_RS10870 Protein ID WP_005725755.1
Coordinates 2287808..2288134 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9414_RS10865 Protein ID WP_005757699.1
Coordinates 2287388..2287714 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9414_RS10845 (M9414_10845) 2282824..2283855 + 1032 WP_250269332.1 hypothetical protein -
M9414_RS10850 (M9414_10850) 2284091..2285101 + 1011 WP_083003938.1 protein PlpE -
M9414_RS10855 (M9414_10855) 2285164..2285754 + 591 WP_102955899.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M9414_RS10860 (M9414_10860) 2285813..2287333 + 1521 WP_250269333.1 surface lipoprotein assembly modifier -
M9414_RS10865 (M9414_10865) 2287388..2287714 - 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M9414_RS10870 (M9414_10870) 2287808..2288134 - 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9414_RS10875 (M9414_10875) 2288292..2288768 + 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M9414_RS10880 (M9414_10880) 2288842..2289712 - 871 Protein_2096 VirK/YbjX family protein -
M9414_RS10885 (M9414_10885) 2289823..2290440 + 618 WP_250269334.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M9414_RS10890 (M9414_10890) 2290549..2292078 + 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
M9414_RS10895 (M9414_10895) 2292132..2292818 - 687 WP_104884163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T246243 WP_005725755.1 NZ_CP097795:c2288134-2287808 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT246243 WP_005757699.1 NZ_CP097795:c2287714-2287388 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References