Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 777207..777974 Replicon chromosome
Accession NZ_CP097793
Organism Pasteurella multocida strain 21275

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M9417_RS03925 Protein ID WP_015690952.1
Coordinates 777648..777974 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9417_RS03920 Protein ID WP_015690953.1
Coordinates 777207..777533 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9417_RS03900 (M9417_03900) 772662..773696 + 1035 WP_015690957.1 hypothetical protein -
M9417_RS03905 (M9417_03905) 773935..774885 + 951 WP_015690956.1 hypothetical protein -
M9417_RS03910 (M9417_03910) 774972..775574 + 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M9417_RS03915 (M9417_03915) 775633..777153 + 1521 WP_015690954.1 surface lipoprotein assembly modifier -
M9417_RS03920 (M9417_03920) 777207..777533 - 327 WP_015690953.1 HigA family addiction module antitoxin Antitoxin
M9417_RS03925 (M9417_03925) 777648..777974 - 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9417_RS03930 (M9417_03930) 778132..778608 + 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M9417_RS03935 (M9417_03935) 778683..779552 - 870 WP_015690951.1 VirK/YbjX family protein -
M9417_RS03940 (M9417_03940) 779663..780280 + 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M9417_RS03945 (M9417_03945) 780388..781917 + 1530 WP_250264902.1 YifB family Mg chelatase-like AAA ATPase -
M9417_RS03950 (M9417_03950) 781983..782669 - 687 WP_015690949.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T246239 WP_015690952.1 NZ_CP097793:c777974-777648 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT246239 WP_015690953.1 NZ_CP097793:c777533-777207 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References