Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2245503..2246242 Replicon chromosome
Accession NZ_CP097791
Organism Pasteurella multocida strain 41060

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M9419_RS10435 Protein ID WP_064965342.1
Coordinates 2245916..2246242 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9419_RS10430 Protein ID WP_005757699.1
Coordinates 2245503..2245829 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9419_RS10410 (M9419_10410) 2240924..2241973 + 1050 WP_064965345.1 hypothetical protein -
M9419_RS10415 (M9419_10415) 2242210..2243217 + 1008 WP_064965344.1 protein PlpE -
M9419_RS10420 (M9419_10420) 2243268..2243870 + 603 WP_005755098.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M9419_RS10425 (M9419_10425) 2243929..2245449 + 1521 WP_064965343.1 surface lipoprotein assembly modifier -
M9419_RS10430 (M9419_10430) 2245503..2245829 - 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M9419_RS10435 (M9419_10435) 2245916..2246242 - 327 WP_064965342.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9419_RS10440 (M9419_10440) 2246400..2246876 + 477 WP_064965341.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M9419_RS10445 (M9419_10445) 2246951..2247820 - 870 WP_064965340.1 VirK/YbjX family protein -
M9419_RS10450 (M9419_10450) 2247931..2248548 + 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M9419_RS10455 (M9419_10455) 2248657..2250186 + 1530 WP_064965339.1 YifB family Mg chelatase-like AAA ATPase -
M9419_RS10460 (M9419_10460) 2250240..2250926 - 687 WP_064965338.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12846.66 Da        Isoelectric Point: 9.6705

>T246238 WP_064965342.1 NZ_CP097791:c2246242-2245916 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTTGLYSIRVNV
KYRLIFKYKESNSPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT246238 WP_005757699.1 NZ_CP097791:c2245829-2245503 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References