Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4087129..4087387 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag M9O78_RS19360 Protein ID WP_000809168.1
Coordinates 4087235..4087387 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4087129..4087186 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS19345 4083521..4084480 + 960 WP_000871674.1 hypothetical protein -
M9O78_RS19350 4084518..4085417 - 900 WP_001300855.1 transcriptional activator NhaR -
M9O78_RS19355 4085483..4086649 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4087129..4087186 - 58 - - Antitoxin
M9O78_RS19360 4087235..4087387 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
M9O78_RS19365 4087491..4088621 - 1131 WP_001118464.1 molecular chaperone DnaJ -
M9O78_RS19370 4088710..4090626 - 1917 WP_000516135.1 molecular chaperone DnaK -
M9O78_RS19375 4091002..4091406 + 405 WP_000843584.1 DUF2541 family protein -
M9O78_RS19380 4091432..4092145 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T246209 WP_000809168.1 NZ_CP097726:4087235-4087387 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT246209 NZ_CP097726:c4087186-4087129 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References