Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 739019..739712 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M9O78_RS03590 Protein ID WP_000415584.1
Coordinates 739019..739315 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M9O78_RS03595 Protein ID WP_000650107.1
Coordinates 739317..739712 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS03555 (734098) 734098..734412 - 315 WP_000958598.1 putative quinol monooxygenase -
M9O78_RS03560 (734443) 734443..735024 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M9O78_RS03565 (735352) 735352..735684 + 333 WP_000917684.1 DUF2645 family protein -
M9O78_RS03570 (735730) 735730..737079 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
M9O78_RS03575 (737076) 737076..737735 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M9O78_RS03580 (737887) 737887..738279 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M9O78_RS03585 (738332) 738332..738814 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M9O78_RS03590 (739019) 739019..739315 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M9O78_RS03595 (739317) 739317..739712 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M9O78_RS03600 (739845) 739845..741452 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M9O78_RS03605 (741590) 741590..743848 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T246195 WP_000415584.1 NZ_CP097726:739019-739315 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT246195 WP_000650107.1 NZ_CP097726:739317-739712 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References