Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 633266..634065 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag M9O78_RS03065 Protein ID WP_000347269.1
Coordinates 633266..633730 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag M9O78_RS03070 Protein ID WP_001309780.1
Coordinates 633730..634065 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS03035 (628267) 628267..628701 - 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M9O78_RS03040 (628719) 628719..629597 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M9O78_RS03045 (629587) 629587..630366 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M9O78_RS03050 (630377) 630377..630850 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M9O78_RS03055 (630873) 630873..632153 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
M9O78_RS03060 (632402) 632402..633211 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
M9O78_RS03065 (633266) 633266..633730 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M9O78_RS03070 (633730) 633730..634065 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M9O78_RS03075 (634214) 634214..635785 - 1572 WP_001273738.1 galactarate dehydratase -
M9O78_RS03080 (636160) 636160..637494 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
M9O78_RS03085 (637510) 637510..638280 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T246193 WP_000347269.1 NZ_CP097726:c633730-633266 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT246193 WP_001309780.1 NZ_CP097726:c634065-633730 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References