Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4030455..4030864 Replicon chromosome
Accession NZ_CP097724
Organism Escherichia coli strain MS1494

Toxin (Protein)


Gene name symE Uniprot ID -
Locus tag M9O75_RS19575 Protein ID WP_001534835.1
Coordinates 4030526..4030864 (+) Length 113 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4030455..4030531 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O75_RS19565 (4025643) 4025643..4026953 + 1311 WP_001534837.1 restriction endonuclease subunit S -
M9O75_RS19570 (4027048) 4027048..4030311 + 3264 WP_267326316.1 HsdR family type I site-specific deoxyribonuclease -
- (4030455) 4030455..4030531 - 77 NuclAT_11 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_11 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_11 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_11 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_12 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_12 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_12 - Antitoxin
- (4030455) 4030455..4030531 - 77 NuclAT_12 - Antitoxin
M9O75_RS19575 (4030526) 4030526..4030864 + 339 WP_001534835.1 endoribonuclease SymE Toxin
M9O75_RS19580 (4030952) 4030952..4031086 - 135 WP_001314403.1 hypothetical protein -
M9O75_RS19585 (4031248) 4031248..4031556 + 309 Protein_3836 winged helix-turn-helix domain-containing protein -
M9O75_RS19590 (4031548) 4031548..4032468 - 921 WP_000181193.1 Rpn family recombination-promoting nuclease/putative transposase -
M9O75_RS19595 (4032653) 4032653..4033933 + 1281 WP_001535800.1 DUF445 domain-containing protein -
M9O75_RS19600 (4034049) 4034049..4035200 + 1152 WP_001338076.1 double-cubane-cluster-containing anaerobic reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12310.04 Da        Isoelectric Point: 7.8226

>T246189 WP_001534835.1 NZ_CP097724:4030526-4030864 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISNKTPR

Download         Length: 339 bp

Antitoxin


Download         Length: 77 bp

>AT246189 NZ_CP097724:c4030531-4030455 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References