Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2440507..2441069 Replicon chromosome
Accession NZ_CP097724
Organism Escherichia coli strain MS1494

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag M9O75_RS11765 Protein ID WP_000605675.1
Coordinates 2440507..2440785 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag M9O75_RS11770 Protein ID WP_000781370.1
Coordinates 2440785..2441069 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O75_RS11740 (2436095) 2436095..2436526 - 432 WP_000152305.1 peroxiredoxin OsmC -
M9O75_RS11745 (2436871) 2436871..2437086 + 216 WP_000495766.1 biofilm-dependent modulation protein -
M9O75_RS11750 (2437188) 2437188..2437325 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
M9O75_RS11755 (2437481) 2437481..2439178 + 1698 WP_000433462.1 malate dehydrogenase -
M9O75_RS11760 (2439311) 2439311..2440321 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
M9O75_RS11765 (2440507) 2440507..2440785 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O75_RS11770 (2440785) 2440785..2441069 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
M9O75_RS11775 (2441298) 2441298..2441951 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
M9O75_RS11780 (2441944) 2441944..2442828 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
M9O75_RS11785 (2442841) 2442841..2445888 - 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T246185 WP_000605675.1 NZ_CP097724:2440507-2440785 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT246185 WP_000781370.1 NZ_CP097724:2440785-2441069 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References