Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4519317..4519919 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M9O79_RS21610 Protein ID WP_000897305.1
Coordinates 4519608..4519919 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9O79_RS21605 Protein ID WP_000356397.1
Coordinates 4519317..4519607 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS21580 (4515243) 4515243..4516145 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M9O79_RS21585 (4516142) 4516142..4516777 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M9O79_RS21590 (4516774) 4516774..4517703 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
M9O79_RS21595 (4518033) 4518033..4518275 - 243 WP_001086388.1 protein YiiF -
M9O79_RS21600 (4518494) 4518494..4518712 - 219 WP_001297075.1 CopG family transcriptional regulator -
M9O79_RS21605 (4519317) 4519317..4519607 - 291 WP_000356397.1 NadS family protein Antitoxin
M9O79_RS21610 (4519608) 4519608..4519919 - 312 WP_000897305.1 hypothetical protein Toxin
M9O79_RS21615 (4520148) 4520148..4521056 + 909 WP_001162704.1 alpha/beta hydrolase -
M9O79_RS21620 (4521120) 4521120..4522061 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M9O79_RS21625 (4522106) 4522106..4522543 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
M9O79_RS21630 (4522540) 4522540..4523412 - 873 WP_000920762.1 virulence factor BrkB family protein -
M9O79_RS21635 (4523406) 4523406..4524005 - 600 WP_001295269.1 glucose-1-phosphatase -
M9O79_RS21640 (4524104) 4524104..4524889 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246169 WP_000897305.1 NZ_CP097721:c4519919-4519608 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT246169 WP_000356397.1 NZ_CP097721:c4519607-4519317 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References