Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3635826..3636367 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag M9O79_RS17505 Protein ID WP_000615976.1
Coordinates 3636089..3636367 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag M9O79_RS17500 Protein ID WP_000729704.1
Coordinates 3635826..3636086 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS17475 (3631609) 3631609..3632394 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
M9O79_RS17480 (3632366) 3632366..3634078 + 1713 Protein_3418 flagellar biosynthesis protein FlhA -
M9O79_RS17485 (3634183) 3634183..3634461 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
M9O79_RS17490 (3634454) 3634454..3634810 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
M9O79_RS17495 (3634867) 3634867..3635640 - 774 WP_000543895.1 C40 family peptidase -
M9O79_RS17500 (3635826) 3635826..3636086 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
M9O79_RS17505 (3636089) 3636089..3636367 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
M9O79_RS17510 (3636523) 3636523..3637263 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
M9O79_RS17515 (3637234) 3637234..3638001 - 768 WP_000333380.1 class II glutamine amidotransferase -
M9O79_RS17520 (3638207) 3638207..3638785 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T246164 WP_000615976.1 NZ_CP097721:3636089-3636367 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT246164 WP_000729704.1 NZ_CP097721:3635826-3636086 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References